República de Cuba Nightlife began as a serious LGBT+ rival to the Zona Rosa only about 15 years ago. Prior to that, the street showed off a lively, and often gay, night scene more similar to the mixed scene on Eje Central, and the 20th-century dance halls across the way in the Colonia Guerrero. Clubs were especially focused on Latin dance and rhythms. Some of these LGBT+ cantinas and dance halls lasted decades. A few were still open even just a few years ago.
Today, a somewhat younger crowded congregates especially in a few places around the intersection with Callejon Heroes de 57. This is just a block east of the Eje Central. But the influence has not been negligible. Clubs have been renamed, closed, remodeled and reopened. Some even multiple times.
For LGBT+ travelers, República de Cuba Nightlife extends even up the Eje to the Plaza Garibaldi. A few other smaller nightspots have opened on Belisario Dominguez. While Republica de Cuba is not lined with venues in a forever party, it will often be crowded with late-night revelers headed in and out of its the multiple venues. There are vendors, too. Many of them cater specifically to the night time crowds, so you can get a bite to eat too. During and after the annual Pride March, visitors are likely to find standing-room-only conditions.