The Turibus Historic Center Circuit is far and away the most popular and heavily traveled route the bus line offers. With hop-on hop-off service it's always easy to get in and around all of the most important places in Mexico City.
Some ticket plans will let you board other routes for one low-rate. But the Turibus Historic Center Circuit covers most of the Paseo de la Reforma, south into chic Condesa and Roma, and a good part of the Centro Histórico too. Not bad for a bus that's arriving every 20-25 minutes.
*It's important to note here that, to simplify the map, we've only shown you the bus-stops. Click on any of them to learn more about that site AND all the other places nearby.